Miles Congreve Selected Research

oxazine 1

1/2020

Structure-Based Drug Discovery of N-((R)-3-(7-Methyl-1H-indazol-5-yl)-1-oxo-1-(((S)-1-oxo-3-(piperidin-4-yl)-1-(4-(pyridin-4-yl)piperazin-1-yl)propan-2-yl)amino)propan-2-yl)-2'-oxo-1',2'-dihydrospiro[piperidine-4,4'-pyrido[2,3-d][1,3]oxazine]-1-carboxamide (HTL22562): A Calcitonin Gene-Related Peptide Receptor Antagonist for Acute Treatment of Migraine.

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Miles Congreve Research Topics

Disease

5	Neoplasms (Cancer) 01/2020 - 06/2003
2	Alzheimer Disease (Alzheimer's Disease) 01/2022 - 11/2021
2	Cognitive Dysfunction 11/2021 - 01/2021
1	Abdominal Pain (Pain, Abdominal) 01/2022
1	Diarrhea 01/2022
1	Headache (Headaches) 01/2022
1	Nausea 01/2022
1	Fatigue 01/2022
1	Hyperhidrosis 01/2021
1	Migraine Disorders (Migraine) 01/2020
1	Crohn Disease (Crohn's Disease) 12/2016
1	Neoplasm Metastasis (Metastasis) 12/2016
1	Inflammatory Bowel Diseases (Inflammatory Bowel Disease) 12/2016
1	HIV Infections (HIV Infection) 12/2016
1	Parkinson Disease (Parkinson's Disease) 09/2011
1	Rheumatoid Arthritis 06/2003
1	Hypertension (High Blood Pressure) 06/2003
1	Obesity 06/2003

Drug/Important Bio-Agent (IBA)

3	Cholinergic Agents (Cholinergics)IBA 01/2022 - 01/2021
2	Muscarinic M1 ReceptorIBA 01/2022 - 11/2021
2	Pharmaceutical PreparationsIBA 01/2020 - 12/2016
1	Donepezil (Aricept)FDA LinkGeneric 01/2022
1	LigandsIBA 01/2020
1	piperidineIBA 01/2020
1	Adenosine (Adenocard)FDA LinkGeneric 01/2020
1	Immune Checkpoint InhibitorsIBA 01/2020
1	Calcitonin Gene-Related Peptide Receptor AntagonistsIBA 01/2020
1	durvalumabIBA 01/2020
1	oxazine 1IBA 01/2020
1	Adenosine A2A Receptor (Adenosine A2A Receptors)IBA 11/2018
1	CCX282-BIBA 12/2016
1	plerixafor FDA Link 12/2016
1	Maraviroc FDA Link 12/2016
1	CCR ReceptorsIBA 12/2016
1	XanthineIBA 09/2011
1	Heat-Shock Proteins (Heat-Shock Protein)IBA 08/2010
1	Molecular Chaperones (Chaperone, Molecular)IBA 08/2010
1	resorcinol (resorcin)IBA 08/2010
1	Tyrosine (L-Tyrosine)FDA Link 06/2003
1	Insulin ReceptorIBA 06/2003
1	AcidsIBA 06/2003
1	Protein Tyrosine PhosphatasesIBA 06/2003
1	EnzymesIBA 06/2003
1	Non-Receptor Type 1 Protein Tyrosine PhosphataseIBA 06/2003

Therapy/Procedure

1	Hematopoietic Stem Cell Mobilization 12/2016